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Spectrophotometric Methods For The Determination Of Nateglinide In Tablets

Author(s): G Vidya Sagar, N. V. S Gangadhara Rao, B. S Sastry

Two simple and sensitive spectrophotometric methods for the determination of nateglinide in bulk samples and tablets are described. Method A (λmax 520 nm) is based on the reaction of drug with brucine and sodium metaperiodate under acidic conditions forming light pink coloured brucipuinone derivative while method B (λmax 455 nm) is based on the reaction of the drug with sodium 1,2-napthoquinone-4-sulphonate forming reddish orange chromogen. The concentration measurements are reproducible with a relative standard deviation of 1%.


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