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Spectrophotometric Methods For The Determination Of Salmeterol Xinafoate

Author(s): M. N Reddy, K. V Rao Kanna, S. S Rao, M. E Rao

Two simple and accurate spectrophotometric methods (A and B) have been developed for the determination of salmeterol xinafoate (SX) and its dosage forms. SX in 0.05 M sodium hydroxide (NaOH) exhibits maximum absorption at a wave length of 247 nm and shows linearity in the concentration range of 1-14 μg/ml in method A. In method B, SX forms a stable bluish green chromogen on treatment with ferric chloride, potassium ferricyanide and hydrochloric acid, showing maximum absorption at 738 nm. The chromogen obeys Beer's law in the concentration range of 0.5-5 μg/ml.


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