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Spectrophotometric Methods For The Estimation Of Nicorandil In Tablet Dosage Forms

Author(s): C. N Patel, S. A Patel, M. M Patel

Two simple, sensitive, accurate and rapid spectrophotometric methods have been developed for the estimation of nicorandil in tablets. Method A is based on the reaction of nicorandil with sulphanilic acid reagent in presence of cyanogen bromide solution giving yellow chromogen, which show maximum absorbance at 460 nm against reagent blank while method B is based on the estimation of nicorandil in 0.1 N HCI at 262 nm. Beer's law was obeyed in the concentration range of 10-80 μg/ml in method A and 5-40 μg/ml in method B. Results of the analysis were validated statistically and by recovery studies.


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