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Spectrophotometric quantitation of metformin in bulk drug and pharmaceutical formulations using multivariate technique

Author(s): MS Arayne1, Najma Sultana2, MH Zuberi1, FA Siddiqui1
1 Department of Chemistry, University of Karachi, Karachi-75270, Pakistan 2 Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

Correspondence Address:
M S Arayne Department of Chemistry, University of Karachi, Karachi-75270 Pakistan [email protected]

A sensitive and accurate UV spectrophotometric method with multivariate calibration technique for the determination of metformin hydrochloride in bulk drug and different pharmaceutical formulations has been described. This technique is based on the use of the linear regression equations by using relationship between concentration and absorbance at five different wavelength. The results were treated statistically and were found highly accurate, precise and reproducible. The method is accurate, precise (% recovery 102.50Î?0.063, CV≤0.56, r =0.997) and linear within the range 1-10 mg/ml. There was no interference from the excipients i.e Povidone K 30, magnesium stearate, lactose and hydroxypropylmethylcellulose. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions.

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