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Abstract

Standardized Extract (HemoHIM) From Angelica gigas nakai, Cnidium officinale, Makino and Paeonia lactiflora Pallas Extract Attenuates Acetaminophen-Induced Liver Injury in Human Hepatocellular Carcinoma Cells and Mice Model

Author(s): Da Ae Kwon, Y. S. Kim, Sin Hwa Baek, Seul Ki Kim, H. K. Kim and H. S. Lee*
Efficacy Evaluation Team, Food Science R&D Center, KolmarBNH CO., LTD, 61, Heolleung-ro 8-gil, Seocho-gu, Seoul, 06800, 1Food Safety Team, Kolmar BNH CO., LTD, 22-15, Sandan-gil, Jeonui-myeon, Sejong-Si, 30003, 2Natural Product Research Team, Food Science R&D Center, KolmarBNH CO., LTD, 61, Heolleung-ro 8-gil, Seocho-gu, Seoul, 06800, 3Food Science R&D Center, KolmarBNH CO., LTD, 61, Heolleung-ro 8-gil, Seocho-gu, Seoul, 06800, Republic of Korea

Correspondence Address:
DA AE KWON, Efficacy Evaluation Team, Food Science R&D Center, KolmarBNH CO., LTD, 61, Heolleung-ro 8-gil, Seocho-gu, Seoul, 06800, Republic of Korea, E-mail: [email protected]


In this study, the hepatoprotective effects of the herbal preparation (HemoHIM) against acetaminopheninduced liver injury were investigated in vitro and in vivo. We investigated the messenger Ribonucleic acid expression of antioxidant factors and proinflammatory cytokines in human hepatocellular carcinoma cells treated with acetaminophen. In vivo study, ICR was divided into five groups (n=10): control, acetaminophen, HemoHIM 250, 500 mg/kg body weight and silymarin 200 mg/kg body weight, respectively. Mice were administrated acetaminophen (350 mg/kg body weight) on d 5 after sample administration. Blood samples were collected for aspartate aminotransferase, alanine transaminase assessment. Liver tissue was determined for glutathione, triglyceride, cholesterol and histopathological features. HemoHIM has significant effects in the treatment groups compared to acetaminophen group.

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