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Abstract

Studies On Diorganoselenium Compounds And Their Tellurium Analogs As Potential Acetylcholinesterase Inhibitors

Author(s): Y. D Kulkarni, P. K Seth, S Srivastava

Few diorganoselenium dihalides and their tellurium analogs have been synthesises. The effect of these compounds on acetylcholinesterase (AChE) activity in rat brain was studies in vitro at different concentrations. Both organoselenium as well as organo tellurium compounds inhibited the AChE activity. At a concentration of 10-4M compound (Ar CO CH2)2 SeBr2 and (Ar CO2) Se Cl2 inhibited the AChE activity by 94.14% and 78.11% while their tellurium analoges at the same concentration exhibited 79.36 and 59.37% inhibition respectively. However, at a lower, concentration of 10-6M, no appreciable difference in AChE Inhibitory activity of organoslenum compounds and their tellurium analogs was observed.

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