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Studies On Protective Effects Of Glutathione and ?-Tocopherol on Norethindrone Induced Lipid Peroxidation

Author(s): De Kakali, K Roy, A Saha, C Sengupta

Studies on possible antiperoxidative property of glutathione (GLU) and α-tocopherol (TOC) on lipid peroxidation (LP) induced by norethindrone (NE), an antifertility drug, were carried out using goat liver homogenate as the lipid source. The study was aimed at exploring possible potential of the antioxidants to reduce druginduced toxicity that may be mediated through free radical mechan1sm. The degree of peroxidation was quantitated by thiobarbituric acid reactive substance (TEARS) content. The present study revealed that both GLU and TOC could significantly suppress NE-induced lipid peroxidation. Considering lipid peroxidation as a toxicity mediating process, the findings are interesting and provide a scope for further extensive studies on the antioxidants with an aim to increase therapeutic index of the drug.


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