Abstract

The effects of anti-inflammatory medications on inflammation control in elderly patients with chronic diseases, along with their potential mechanisms and side effects, were investigated in this study. A randomized controlled trial divided 120 elderly patients with chronic conditions into two groups. Conventional treatment was administered to one group, while the other group was subjected to conventional treatment in addition to anti-inflammatory medications (aspirin or ibuprofen). Changes in blood biochemical markers, levels of inflammatory cytokines, clinical symptoms, and quality of life were compared before and after treatment in both groups and statistical analysis were performed. The study revealed that serum levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha were effectively reduced in elderly patients with chronic diseases by anti-inflammatory medications. Additionally, improvements in clinical symptoms and quality of life were observed, but an increased risk of side effects such as bleeding, gastrointestinal adverse reactions, and renal impairment was also noted. It is suggested that anti-inflammatory medications exhibit a certain degree of inflammation control in elderly patients with chronic diseases; however, their use should be approached judiciously, considering individual circumstances and conducting risk assessments.