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Study of anti ulcer activity of sodium metavanadate on alcohol and pylorus ligation induced gastric ulcers in rats

Author(s): PB Suthar, SM Jain, AA Mehta, DD Santani
Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad - 380 009, India

Correspondence Address:
P B Suthar Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad - 380 009 India E-mail: [email protected]

The present study was designed to evaluate the effects of sodium metavanadate against experimentally-induced gastric ulcers. In an attempt to establish the antiulcer effect and its mechanism of action, sodium metavanadate (3, 5 mg/kg, i.p.) was studied in ethanol and pylorus ligation-induced gastric ulcer models. Sodium metavanadate significantly reduced ulcer index in both the ulcer models. Besides it showed significant reduction in total acid out put along with significant rise in total carbohydrates and mucin activity in gastric juice in pylorus ligation model. Therefore, it is suggested that sodium metavanadate possesses significant antiulcer activity. The probable mechanisms for its antiulcer effect can be attributed to decrease in acid secretion and increase in mucoprotective substances.

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