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Study of the complexation behaviour of fexofenadine with ?-cyclodextrin

Author(s): Nidhi P Sapkal1, Vaishali A Kilor1, Bharti D Shewale2, KP Bhusari3, AS Daud4
1 Gurunanak College of Pharmacy, Near Dixit Nagar, Nari, Nagpur-440 026, India 2 H. R. Patel women's College of Pharmacy, Shirpur-425 405, India 3 Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441 110, India 4 Zim Laboratories Ltd. Kalmeshwar, Nagpur-441 501, India

Correspondence Address:
Nidhi P Sapkal Gurunanak College of Pharmacy, Near Dixit Nagar, Nari, Nagpur-440 026 India E-mail: [email protected]

Fexofenadine is a selective histamine H 1 receptor antagonist, used for relief of the symptoms of allergy. However its aqueous solubility is very poor. Solid inclusion complexes of fexofenadine and β-cyclodextrin were prepared at the molar ratios of 1:1 and 1:2 by kneading, and coprecipitation methods to improve its solubility. Characterization of the complexes was performed using infrared spectroscopy, X-ray diffractometry, and in vitro dissolution studies. Fexofenadine was found to exhibit interaction with β-cyclodextrin both in solid and liquid state. Phase solubility studies indicated that fexofenadine forms a stable complex with β-cyclodextrin. Both IR spectroscopy and X-ray diffractometry studies indicated interaction of fexofenadine with β-cyclodextrin. Kneading method at 1:1 and co-precipitation method at 1:1 and 1:2 molar ratios showed significant interaction. In vitro dissolution studies confirmed the same results.

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