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Abstract

Study on Effect of Simvastatin on Regeneration of Hippocampal Dentate Gyrus Nerve after Cerebral Ischemia in Rats

Author(s): Z. MA, NA GUO, H. MA1, XUENA MA1, Y. XU AND L. GENG*
Department of Critical Care Medicine, The Fourth Central Hospital of Baoding City, Baoding City, 072350, Hebei province, 1Department of Neurology, The Fourth Central Hospital of Baoding City, Baoding City, 072350, Hebei province, China

Correspondence Address:
L. GENG, Department of Critical Care Medicine, The Fourth Central Hospital of Baoding City, Baoding City, 072350, Hebei province, China, E-mail: [email protected]


This study is to explore the effect of simvastatin on regeneration of hippocampal dentate gyrus nerve after cerebral ischemia in rats. Morris water maze test is an important experimental method which has been established to judge the learning and memory of animals in the last twenty years. Except for the sham operation group, animals in the other two groups show neurologic impairment of varying degrees after waking, characterized by turning to the affected side, toppling, being unable to stand, and being unable to walk. The number of bromodeoxyuridine positive cells in simvastatin group is significantly larger than that in middle cerebral artery occlusion group, indicating that statins may play a role in promoting nerve regeneration, alleviating brain tissue damage and improving prognosis after cerebral ischemia. We haven’t made the mechanism of simvastatin for promoting nerve regeneration clear-cut, and some scholars believe that simvastatin may regulate neural cell apoptosis by influencing cell signaling pathway.

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