Abstract

We attempt to study the effect of mild hypothermia combined with postural intervention on meropenem intervention in patients with craniocerebral trauma and its impact on prognosis. We selected eighty patients with craniocerebral trauma who received meropenem intervention in hospital from February 2020 to February 2023 for the trial. Then divided them into an experimental group (n=40 cases) and a reference group (n=40 cases) according to the computer-numbered random number table method. Reference group received conventional nursing intervention, after receiving the same intervention as reference group, added mild hypothermia combined with postural intervention to the experimental group. Compared both groups on the results of the intervention, serum calcitonin gene-related peptide, myelin basic protein and brain-derived neurotrophic factor levels, complications and prognosis. After 2 w of intervention, experimental group had lower the national institutes of health stroke scale scores, but higher the Glasgow coma scale scores than reference group (all p<0.05). After 2 w of intervention, experimental group had higher serum calcitonin gene-related peptide and brain-derived neurotrophic factor levels but lower myelin basic protein levels than reference group (all p<0.05). The overall complication rate in the experimental group was lower than that in the reference group (10.00 % vs. 30.00 %) (p<0.05). After 2 w of intervention, Glasgow prognostic scale scores were higher in both groups than before the intervention and experimental group had higher scores than reference group (all p<0.05). The effect of mild hypothermia combined with postural intervention on meropenem intervention in patients with craniocerebral trauma is better and can promote the improvement of patient’s neurological function and prognosis, which is worthy of promotion and application.