Abstract

The aim of this study is to investigate the impact of palliative care on the treatment of acute lymphoblastic leukemia with pegaspargase in children. A hundred children with acute lymphoblastic leukemia received treatment at our hospital's hematology department from October 2021 to September 2022 and were randomly distributed to the observation and control groups. Both groups received the treatment of vincristine, daunorubicin, pegaspargase and prednisone. While the observation group underwent palliative care, the control group received regular nursing care simultaneously. We conducted a statistical analysis of adverse reactions, quality of life, and negative emotion improvement in both groups to assess the potential impact of palliative care on acute lymphoblastic leukemia. Significantly lower occurrence of adverse reactions and self-rating anxiety scale/self-rating depression scale scores were observed in the observation group compared to the control group, along with higher scores for physical, emotional, academic and daily-life functional capability. Palliative care can effectively mitigate the adverse reactions of chemotherapy, enhance the quality of life, and improve the psychological state of children with acute lymphoblastic leukemia.