Abstract

To research the effectiveness of Zhigancao decoction in treating upper gastrointestinal bleeding when used in conjunction with Western therapy. The two groups of 109 patients with upper gastrointestinal bleeding who were admitted to our hospital between January 2022 and January 2023 were compared with regard to the total effective rate of therapy, haemostatic impact, traditional Chinese medicine evidence score, blood rheological index and serum-related parameters. The research group (n=54, utilizing Zhigancao decoction in addition to Western medication) and the control group (n=55, receiving only Western medical treatment) were randomized into the two groups at random. The study group's total treatment efficacy rate was greater (p<0.05) compared to the control group. In comparison to the control group, the research group's hemostasis time, blood pressure stabilization time, and time to treat abdominal discomfort were all shorter (p<0.05). After treatment, the traditional Chinese medicine syndrome scores of the research group were lower than those of the control group (p<0.05). Following treatment, the research group's erythrocyte sedimentation rate was lower than that of the control group (p<0.05), and their levels of polycythemia vera, whole blood high cut viscosity, and whole blood low cut viscosity were all higher than those of the control group (p<0.05). Serum 6-keto-prostaglandin F1 alpha and malondialdehyde levels were lower (p<0.05), superoxide dismutase and prostaglandin E2 levels were lower (p<0.05) in the research group than in the control group following treatment. The treatment of upper gastrointestinal bleeding with Zhigancao decoction as an adjunct to Western medicine can further enhance the hemostatic effect and effectively improve the hemodynamic status. The down-regulation of prostaglandin E2 and 6-keto-prostaglandin F1 alpha levels as well as the body’s reduced stress response may be part of the mechanism of action.