Synthesis and antibacterial activity of 7-ethoxy-4-(substituted)-aminomethylcoumarins.
Dept. of Chemistry, Sri Krishnadevarayya University, Anantapur-515 003,
M Nagesam Dept. of Chemistry, Sri Krishnadevarayya University, Anantapur-515 003
A series of 7-ethoxy-4-substituted aminomethylcoumarins have been synthesised making use of the selective reactivity of methyl and formyl groups in position-4 of coumarin nucleus. All these compounds have been screened for their antibacterial activity. Compounds with anilinomethyl, picolinylaminomethyl function in position-4 of coumarin ring system showed higher inhibition of bacterial growth. The other compounds showed only moderate activity.PDF