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Synthesis and antibacterial assessment of N -[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine

Author(s): P Gahtori1, A Das2, H Bhatt2
1 Department of Pharmacy, Kumaun University, Bhimtal-263 136, India 2 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, India

Correspondence Address:
P Gahtori Department of Pharmacy, Kumaun University, Bhimtal-263 136 India [email protected]

In a wide search program towards new and efficient antibacterial agents, we assessed the extent to which physicochemical properties can be exploited to promote antibacterial activity associated with a series of substituted s-triazine. The synthesized compounds (1a-12b) were subsequently screened for their in vitro antibacterial activity against three gram positive ( Bacillus subtilis, Bacillus cereus, Staphylococcus aureus ) and three Gram-negative microorganism ( Salmonella typhi, Escherichia coli, Klebsiella aerogenes ) by the broth dilution technique, recommended by European Committee for antimicrobial susceptibility testing with reference to streptomycin.

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