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Synthesis And Anti-HIV Studies Of Some Substituted Pyrimidinediones, Ethoxy Pyrano (3,2-C) Quinolines And Hydrazino Pyrano (3,2-C) Quinolines

Author(s): Narsinh Dodia, Anamik Shah

Recent reports1 describe a novel class of 4-hydroxycoumarins and its derivatives as Non-nucleoside Reverse Transscriptase lnhibitiors (NNRTls) In the Human immunodeficiency Virus (HIV). The chemistry of 4-hydroxycoumarins and 4-hydroxy carbostyryls (4-hydroxy 2-quinolones) was much studied for evaluating tautomerism and pharmacology as well2-4. Our current interest Is to synthesize pyrano [3,2-c) quinolines and their transformation into a variety of fused heterocycles substituted at 3,4 - positions, which may prove to be interesting antiviral agents.


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