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Abstract

Synthesis and antiinflammatory activity of 3-substituted-4-amino-5-mercapto-4(h)-1,2,4-triazole.

Author(s): MC Hosur, MB Talwar, RS Bennur, SC Benur, PA Patil, S Sambrekar
Post-graduate, Dept. of Studies in Chemistry, Karnatak University, Dharwad-580 003,

Correspondence Address:
M C Hosur Post-graduate, Dept. of Studies in Chemistry,, Karnatak University, Dharwad-580 003

"Various 3-substituted-4-amino-5-mercapto-4(H)- 1,2,4-triazoles were synthesised by treating morpholine/piperidine acetic/propionic/(alpha-methyl) propionic acid hydrazides successively with alcoholic potassium hydroxide-carbondisulfide and hydrazine hydrate.All the compounds were screened for their antiinflammatory activity against carrageenan induced rat paw edema and cotton pellet granuloma pouch at mg/100 grams B.W. Three compounds [B,C,D] were found to have significant activity. The detailed antiinflammatory activity and acute toxicity were studied, the former in comparison with phenyl butazone."

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