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Synthesis And Anti-Inflammatory And Analgesic Activities Of 2-Arylamino 4-(4-Chlorophenyl) Thiazole-5-Acetic Acids/Esters

Author(s): M Attimarad, G Bagavant

New substituted 2-amino-4-(4-chlorophenyl) thiazole-5-acetic acids (6a-k) and esters (7a-l) were prepared by condensaton of thioureas with methyl 3-bromo-3-(4-chlorobenzoyl) propionate. The compounds showed good anti-inflammatory (55-80%, ibuprofen 85%) and analgesic (40-58%, aspirin 57%) activities.


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