Abstract
Synthesis and antimicrobial activity of 5-imidazolinone derivatives
Author(s): NC Desai, AM Bhavsar, BB Baldaniya
Medicinal Chemistry Division, University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002, India
Correspondence Address:
N C Desai Medicinal Chemistry Division, University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002 India dnisheeth@rediffmail.com
Medicinal Chemistry Division, University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002, India
Correspondence Address:
N C Desai Medicinal Chemistry Division, University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002 India dnisheeth@rediffmail.com
Several 4-arylidene-2-phenyl-1-(2,4,5-trichlorophenyl)-1H-imidazol-5(4H)-ones (4a-q), N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-4-chlorobenzamides (5a-o) and N-(4-benzylidene-5-oxo-2-phenyl-4,5-dihydroimidazol-1-yl)-2,4-dichlorobenzamides (6a-m) were prepared. All newly synthesized compounds have been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of OH, OCH 3 , NO 2 , Cl and Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.
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