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Synthesis And Antimicrobial Activity Of Some New 1,2,4-Triazoles

Author(s): T. K Ravi, R Rajkannan

A variety of 1,2,4-triazole derivatives were synthesized by esterifying substituted aryl carboxylic acid separately. It was then treated with hydrazine hydrate to yield corresponding aromatic acid hydrazides. When these hydrazides were treated with KOH and CS2, oxadiazoles were obtained. Thus obtained oxadiazoles on further treatment with different acid hydrazides afforded three different series of 1,2,4-triazole derivatives. All the newly synthesized compounds were screened for their antimicrobial activities and 1,2,4-triazoles of anthranilic acid series were found to be very active than the other two series of compounds.


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