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Synthesis And Antitubercular Activity Studies Of Some Unsymmetrical 1,4-Dihydropyridines

Author(s): H Gaveriya, B Desai, V Vora, A Shah

Unsymmetrical 1,4-dihydropyridines having isoxazole and pyridine system been synthesized from 2,6-dimethyl-4[3"-nitrophenyl]-5-carbmethoxy-3-[3"-aryl propene-1"-one]-1,4 dihydropyridines of the type la-h. All compounds were tested for antitubercular activity against M.tuberculosis (H37Rv)strain by using Bactec 460 method. lsoxazole derivatives showed modest activity.