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Synthesis And Biological Activities Of New 2-Substituted-5,6-Dichlorobenzothiazoles

Author(s): V Murugan, V Sekar, G. V. S Rama Sarma, Y. S. R Reddy, B Suresh

New 2-(4-formyl-3-phenylpyrazolo-1-yl)-amidomethyl-5,6-dichloro-benzothiazole (III) was synthesized by reacting acetophenone-5,6-dichlorobenzothiazol-2-yl amidomethylhydrazone(II) with Vilsmeier-Haack reagent (DMF/POCl3). Benzaldehyde/4-nitrobenzaldehyde/4-methoxy benzaldehyde-5,6-dichlorobenzothiazol-2-yl amidomethylhydrazones (IV-VI) were obtained by the reaction of 2-hydrazinoamidomethyl-5,6- dichlorobenzothiazole (I) with various aromatic aldehydes. All these compounds were characterised by analytical and spectral data. Compound (III) exhibited good antiinflammatory and antibacterial properties while the rest of the compounds were moderately active, on evaluation.


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