Synthesis and evaluation of antifungal and antibacterial activity of 2-amino- and 2-mercapto-4-(2',3'-dihydro-2'-methylbenzofuran-5'-yl) thiazoles and their derivatives.
Department of Chemistry, University of Delhi, Delhi 110 007
V K Ahluwalia Department of Chemistry, University of Delhi, Delhi 110 007
Synthesis of 2-amino-4-(2,3-dihydro-2-methylbenzofuran-5-yl) thiazole and 2-mercapto-4-(2,3-dihydro-2-methyl benzofuran-5-yl) thiazole have been carried out starting from 5-acetyl-2,3-dihydro-2-methylbenzofuran. These compounds have shown marginal activity when tested against Aspergillus fumigatus, Aspergillus niger Staphylococcus aureus and Escherichia coli at 25 and 50 mcg ml concentrations.PDF