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Abstract

Synthesis And Evaluation Of Antiinflammatory Activity Of Ibuprofen Analogs

Author(s): A Rajasekaran, P Sivakumar, B Jayakar

N-hydroxy methyl derivative of 2(4-isobutyl phenyl) propionamide was synthesised and condensed with seven different active hydrogen containing compounds (antipyrine, pyrrolidine, piperidine, phthalimide, morpholine, piperazine and hydrazine). These compounds were characterised by their analytical and spectral data. The antiinflammatory activity of the synthesised compounds was evaluated by carrageenan-induced rat paw oedema method and the compounds with pyrrolidine, phthalimide and hydrazine showed potent antiinflammatory activity.

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