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Synthesis And Evaluation Of Some Novel 2-(Substituted Amino) Benzimidazoles as H1-Receptor Blockers

Author(s): V Alagarasamy, A Thangathiruppathy, C Bothiraja, P Saravanakumar, G Sathyabalan, S Rajkumar

A variety of novel 2-(substitute amino) benzimidazoles have been synthesized by the cyclocondensation of o-phenylenediamine with a variety of dithiocarbamic esters. The title compounds were tested for their H1 - antihistaminic activity on isolated guinea pig ileum. While all the test compounds exhibited antihistaminic activity, the compound IVa was found to be more potent than the standard pheniramine maleate.


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Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report