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Abstract
Synthesis and in vitro antitubercular activity of 7-substituted fluoroquinolones
Author(s): AV Shindikar, CL Viswanathan
Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098, India
Correspondence Address:
C L Viswanathan Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098 India E-mail: chelakara_viswanathan@yahoo.com
Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098, India
Correspondence Address:
C L Viswanathan Department of Pharmaceutical Chemistry, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai - 400 098 India E-mail: chelakara_viswanathan@yahoo.com
Three novel fluoroquinolones with general structure 1-t-butyl-7-[4-substituted (piperazin-1-yl/piperidin-1-yl)]-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acids were synthesized and evaluated for antitubercular activity in vitro against M. tuberculosis H37Rv in Middlebrook 7H9 broth using sparfloxacin, ciprofloxacin and isoniazid as standards. Test compounds were found to be less potent than sparfloxacin; however, one of the compounds was more potent than ciprofloxacin.
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