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Synthesis And Multiple Biological Activities Of Azomethines And 4-Thiazolidinones

Author(s): S.B Hirpara, Khyati Parekh, Hansa Parekh

4-(2-Methoxy-5-methylphenyl)-1-(substituted benzal) thiosemicarbazides Ila-m and 2-(arylidenehydrazono)- 3-(2-methoxy-5-methylphenyl)-4-thiazolidinones Illa-m have been prepared by the condensation of 2-methoxy-5-methylphenyl thiosemicarbazide I with different aromatic carboxaldehydes, which on cyclocondensation with chloroacetic acid in presence of sodium acetate in glacial acetic acid yielded 4-thiazolidinones Illa-m. The characterisation of the compounds have been done on the basis of elemental analyses, IR, IH NMR and mass spectral study. All the compounds have been evaluated for their in vitro growth inhibiting activity against several microbes and most of the compounds have also been screened for antitubercular activity against Mycobacterium tuberculosis H37Rv. Some selected compounds have been evaluated for their in vitro anticancer screen aimed at identifying agents having cell type specificity using batteries of cell lines derived from human solid tumor at National Cancer Institute, U.S.A.


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