All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and pharmacological examination of some thiazolidinone derivatives of naphtho[2,1- b ]furan

Author(s): HM Vagdevi1, VP Vaidya2, KP Latha1, B Padmashali1
1 Department of Chemistry, Sahyadri Science College, Shimoga-577 203, India 2 Department of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451, India

Correspondence Address:
V P Vaidya Department of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577 451 India E-mail: [email protected]

2-Acetylnaphtho[2,1- b ]furan (1), obtained from 2-hydroxy-1-naphthaldehyde was converted into 2-bromoacetylnaphtho[2,1- b ]furan (2), which served as an intermediate for the synthesis of title compounds. The compound (2) was treated with thiourea to get 2-(2-aminothiozol-4-yl)naphtho[2,1- b ]furan (3), which produced 2-(2-arylideneaminothiozol-4-yl)naphtho[2,1- b ]furans (4a-i) on reacting with various aromatic aldehydes. Schiff bases (4a-i) yielded 2-[2-(2-aryl-4-thiazolidinone)thiazol-4-yl]naphtho[2,1- b ]furans (5a-i) on treating with thioglycolic acid. Compound (2) was reacted with different aromatic amines to obtain 2-(N-aryl-2-amino)acetylnaphtho[2,1- b ]furans (6a-k). Similarly reaction with substituted thiourea furnished 2-(2-N-arylaminothiazol-4-yl)naphtho[2,1- b ]furans (7a-k). All the newly synthesized compounds have been characterized by elemental analysis and spectral data, which have been screened for antimicrobial and anthelmintic activities. The selected compounds have been evaluated for antiinflammatory and diuretic activities.

Full-Text | PDF

Google scholar citation report
Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report