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Synthesis And Preformulation Studies Of A Prodrug Of Enoxacin

Author(s): D Chadha, S. P Agarwal

A prodrug of enoxacin was synthesized by reacting with aqueous formaldehyde solution a 1:1 mixture of methanol and dichloromethane. The colourless, crystalline N-hydroxymethyl enoxacin, m.p. 262-266° showed enhanced solubility and dissolution rate. The degradation kinetics, pH-rate profile and antibacterial activity of the prodrug were determined.


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