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Synthesis, anthelmintic and antiacetylcholinesterase activity of newer furan derivatives.

Author(s): DP Gupta, S Ahmad, K Shanker
Deptt. of Pharmacology, K.G'S Medical College, Lucknow-226 003,

Correspondence Address:
D P Gupta Deptt. of Pharmacology, K.G'S Medical College, Lucknow-226 003

1-(2-Furanyl)-3-aryl-2-propenones (I) were cyclised with substituted phenyl hydrazines yielding 1-aryl-5-(2-furanyl)-4,5-dithydro-3-(substituted phenyl)-1H-pyrazoles. The double bond of I was brominated which yielded a dibromo compound (III). (III) on reaction with secondary amines yielded 1-(2-furanyl)-3-substituted-1, 2-disubstituted-3-propanones. The mass and NMR spectra have been discussed. The compounds were screened for acetylcholinesterase inhibitory activity as well as the anthelmintic activity against H. nana.


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