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Synthesis, Antibacterial And Antifungal Activities Of N-Mannich Bases Of 3-(N2- Pyrimethaminylimino) Isatin

Author(s): S. N Pandeya, P Yogeeshwari, D Sriram, G Nath

Schiff base of isatin with pyrimethamine and its N-Mannich bases were synthesized. Their chemical structures have been confirmed by UV, IR, 1H-NMR data and by elemental analyses. Antimicrobial evaluation was done by agar dilution method against 25 pathogenic bacteria and 6 pathogenic fungi. Among the new derivatives evaluated, 2-[1"-(morpholinomethyl)-3"-isatinimino]-5- (4'-chloropheny1)-6-ethyl-4-aminopyrimidne (PY4) exhibited higher potency compared to the standard drugs, against all bacteria. All the compounds exhibited antifungal activity.


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