All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis, Antibacterial And AntiHIV Activities Of 3-(5-Amino-6-(2-3-Dichloro-Phenyl)-(1,2,4) Triazin-3-Yl)-6,8-Dibromo-2-Substituted-3H-Quinozolin-4-One

Author(s): P Selvam, K Girija, G Nagarajan, E De Clercq

A series of novel 2,3-disubstituted/6,8-dibromo-2,3-disubstituted quinazolin-4(3H)-ones have been synthesized by condensing the primary amino group of lamotrigine with benzoxazin-4-one.The structure of the synthesised compounds was elucidated by spectral analysis (IR, NMR and Mass). The compounds synthesized were screened for antibacterial and antiHlV activities against replication of HIV-1 and HIV-2 in acutely infected LIT-4 cells. The compounds SPC-I, SPC-I Brand SPCIII Br (100 μg/ml) exhibited equivalent antibacterial activity with the standard ciprofloxacin (10 μg/ ml) against salmonella typhi. All the compounds exhibited cytotoxic properties in the MT-4 lymphocyte cell line.


List of Supporting Conferences