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Synthesis, antimicrobial screening and structure-activity relationship of some novel 2-hydroxy-5-(nitro-substituted phenylazo) benzylidine anilines

Author(s): AK Halve, R Dubey, D Bhadauria, B Bhaskar, R Bhadauria
School of Studies in Chemistry, Jiwaji University, Gwalior-474 011, India

Correspondence Address:
A K Halve School of Studies in Chemistry, Jiwaji University, Gwalior-474 011 India E-mail: [email protected]

The title compounds were synthesized by the condensation of nitro-substituted 2-hydroxy-5- (nitro-substituted phenylazo) benzaldehyde (3) with different aromatic amines in presence of ethanol in good yield. The chemical structures were confirmed by IR, 1H NMR and elemental analysis. All the synthesized compounds (4a-j) have been evaluated for their in vitro antimicrobial activity against S. aureus , P. aeruginosa , E. coli , A. fumigatus , A. niger and C. neoformans .

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