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Synthesis, Antioxidant and Antidiabetic Activity of 1-[(5-Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole

Author(s): N. Kaushik1*, N. Kumar2 and A. Kumar3
School of Pharmaceutical Sciences, IFTM University, Moradabad–244 102, 1School of Medical and Allied Sciences, Department of Pharmacy, Galgotias University, Greater Noida, Gautam Budh Nagar–201 306, 2Oxford College of Pharmacy, UPSIDC, M-G Road, Ghaziabad–201 001, 3Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut–250 005, India

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A series of 1-[(5-substituted phenyl)-4, 5-dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole derivatives (4a-j) have been synthesized by the reaction of 1-(5-substitutedphenyl-1H-tetrazol-1-yl) prop-2-en-1-one (3a-j) with hydrazine hydrate in acetic acid under reflux for 5 h. Structure of the synthesized compounds was established by their spectral data. As a new strategy for alleviating the oxidative damage in Diabetes mellitus, a growing interest has been observed in the usage of antioxidants. The synthesized compounds were screened for their in vitro antioxidant activity by DPPH free radical scavenging method and in vivo antidiabetic activity by streptozotocin-induced model. Compounds 4b, 4g, 4h and 4j were exhibit prominent antioxidant as well as antidiabetic activity. Compound 4i was exhibit moderate antidiabetic activity.

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