All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, antiviral and cytotoxic activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one derivatives

Author(s): P Selvam1, N Murugesh2, M Chandramohan3, C Pannecouque4, E DE Clercq4
1Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India 2Institute of Pharmacology, Madurai Medical College, Madurai - 625 001, India 3Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai - 625 001, India 4Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B - 3000, Belgium

Correspondence Address:
P Selvam Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436 India E-mail: periyasamy_selvam@yahoo.co.in


A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.

Full-Text | PDF

 
 
Google scholar citation report
Citations : 66710

Indian Journal of Pharmaceutical Sciences received 66710 citations as per google scholar report