Abstract
Synthesis, antiviral and cytotoxic activities of 2-(2-Phenyl carboxylic acid)-3-Phenylquinazolin -4(3H)-one derivatives
Author(s): P Selvam1, N Murugesh2, M Chandramohan3, C Pannecouque4, E DE Clercq4
1Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India 2Institute of Pharmacology, Madurai Medical College, Madurai - 625 001, India 3Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai - 625 001, India 4Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B - 3000, Belgium
Correspondence Address:
P Selvam Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436 India E-mail: periyasamy_selvam@yahoo.co.in
1Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436, India 2Institute of Pharmacology, Madurai Medical College, Madurai - 625 001, India 3Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai - 625 001, India 4Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, Leuven B - 3000, Belgium
Correspondence Address:
P Selvam Department of Pharmaceutical Chemistry, Devaki Amma Memorial College of Pharmacy, Chelembra, Malapuram - 673 436 India E-mail: periyasamy_selvam@yahoo.co.in
A series of novel 2,3-disubstitutedquinazolin-4(3H)-ones have been synthesized by condensation of 2-substituted benzo[1,3]oxazine-4-ones and anthranilic acid. Synthesized compounds were evaluated for in vitro antiviral activity against HIV, HSV and vaccinia viruses. 5-Bromo-2-(6-bromo-4-oxo-2-phenyl-4H-quinazolin-3-yl)-benzoic acid (MBR2) exhibited distinct antiviral activity against Herpes simplex and vaccinia viruses.
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