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Synthesis, Biological Evaluation And QSAR Analysis Of Some New Derivatives Of Ketoprofen And Flurbiprofen

Author(s): N Kawathekar, S. C Chaturvedi

New derivatives of ketoprofen and flurbiprofen were synthesized by Mannich reaction. The Mannich base amides of ketoprofen and flurbiprofen were synthesized using different amines. These were then evaluated for analgesic, anti-inflammatory, ulcerogenic activities and quantitative structure-activity relationship was analysed. Some of the derivatives were found to be potent with practically no ulcerogenic activity.


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Citations : 53647

Indian Journal of Pharmaceutical Sciences received 53647 citations as per google scholar report