All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis, Characterization, Antimicrobial and Density Functional Theory Studies of Metal Complexes of 3-Benzoyl-7-methoxy Coumarin

Author(s): S. Radha, K. K Mothilal1*, A .Thamaraichelvan2 and R. Shanmugam3
Department of Chemistry, Saiva Bhanu Kshatriya College, Aruppukottai-626 101, 1Department of Chemistry, Saraswathi Narayanan College, Madurai-625 002, 2Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chennai-603 103, 3National Centre for Catalysis Research, Indian Institute of Technology Madras, Chennai-600036, India

Correspondence Address:
Department of Chemistry, Saraswathi Narayanan College, Madurai-625 002, India, E-mail: [email protected]

A series of three metal complexes of the 3-benzoyl-7-methoxycoumarin ligand have been synthesized and characterized by elemental analyses, molar conductance, Fourier-transform infrared spectroscopy, thermogravimetric analysis, electron paramagnetic resonance, proton nuclear magnetic resonance spectroscopy and cyclic voltammetry techniques. The infra-red spectra of the ligand and its complexes showed that the ligand behaved as a bidentate and confirmed the presence of nitrate ions in the coordination sphere. Thermal stability of the complexes was studied using thermogravimetric and differential thermal analysis, which supported the presence of nitrate ions in these complexes. All complexes exhibited an octahedral geometry around the metal center. The redox property of the metal complexes was studied cyclic voltametrically, which showed that all the complexes exhibited quasi-reversible nature. Antimicrobial studies of these metal complexes and the ligand were conducted against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Aspergillus niger and Candida albicans species. Metal complexes exerted greater antimicrobial activities compared to the ligand. The optimized structure of the zinc complex of coumarin derivative was obtained using DFT/RB3LYP method with 6-311G++G (d,p) basis set. Density functional theory calculations were performed for the determination of geometry structure and vibrational assignments for the zinc complex.

Full-Text | PDF