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Synthesis Of 1-(2'-Hyroxybenzoyl)-5-(Substituted Phenyl)-3-(2'-Methylindolyl)-2-Pyrazolines As Anti Inflammatory Agents

Author(s): Ekta Bansal, T Ram, V. K Srivastava, Ashok Kumar

1-(2'-hydroxybenzoyl)-5-(substituted phenyl)-3-(2'-methylindolyl)-2-Pyrazolines were prepared by the cyclocondensation of 2-methyl-3-indolyl substituted chalcones with salicylic acid hydrazide through Michael condensation, which in turn were synthesized by the reaction of 3-acetyl-2-methylindole and substituted aromatic aldehydes. These compounds were screened for antiinflammatory activity, ulcerogenic potential, CVS activity and acute toxicity. Compound 1-(2'-hydroxybenzoyl)-5-(2'-fluorophenyl)- 3-(2'-methylindolyl)-2-pyrazoline showed the most potent antiinflammatory activity.


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