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Synthesis of 3,6-diaryl-2H, 3H, 4H, 5H, 6H-[1,3]-Oxazine-2- Thiones As Potential Anticonvulsants

Author(s): C Singh, H. K Parwana, G Singh

It is reported that (-NH-C) and (-C-NH-C) groups are associated with the analgesic and muscle relaxation properties. Therefore, synthesis of eight cyclic thiocarbamates, 3,6-dairly pentahydro- [1,3]-oxazine-2-thiones as potential anticonvulsant drugs have been attempted through cyclisation with thiophosgene of 1-arylamino-3-hydroxy-3-arylpropanes obtained earlier by hydride reduction of 1-arylamino-3-oxo-3-arylpropanes.


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