Synthesis of 9-beta-d-glycopyranosyl xanthotoxal and cns depressant activity of 9 beta-d-arabinopyranosyl xanthotoxol.
Regional Research Laboratory, Canal Road, Jammu-180 001
S M Jain Regional Research Laboratory, Canal Road, Jammu-180 001
A series of beta-D-glycopyranosyl xanthotoxol derivatives has been synthesised and screened for CNS depressant activity. The more active CNS depressant,9-beta-D-arabinopyranosyl xanthotoxol (IX), was selected for detailed study on different pharmacological parameters. It caused dose dependent inhibition of spontaneous motor activity, prolongation of hexabarbitone, pentobarbitone and ether hypnosis.PDF