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Synthesis Of New 4-Thiazolidinones And 2-Azitidiones With Their In Vitro Biological Activities

Author(s): Mazaahir Kidwai, Renu Bala, Kaushlendra Kumar

A series of 2-aryl-3-[(3'5'-dinitrobenzamido)]-thiazolidin-4-ones and N-[3'5'-dinitrobenzamido]-3-chloro-4-(aryl substituted) azetidin-2-ones have been prepared and examined for antibacterial and antifungal activity in vitro against E.coli (gram negative), S. aurus (gram positive) and A.niger, A. flavous respectively. The reaction of 3,5-dinitrobenzoic acid with thienyl chloride in the presence of dry methanol yields 3,5-dinitro-benzoate, on condensation with various aromatic aldehyde gave 2-(3'5'- dinitrobenzoyl) hydrazones, which on cycle-addition with thioglycollic acid and chloracetyl chloride gave 2-aryl-3-[(3'5'-dinitrobenzamido)]-thiazolidin-4-ones and N-[3,5,- dinitrobenzamido] -3-chloro-4-(aryl substituted)-azetidine-2-ones respectively.


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