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Synthesis Of Newer Indolyl Thiadiazoles And Their Thiazolidinones And Formazans As Potential Anticonvulsant Agents

Author(s): Archana, V.K Srinivastava, Ashok Kumar

A series of 2-(substituted arylidenyl imino)-5-(3' indolomethylene)-1,3,4-thiadiazoles have been synthesized via condensation of 2-amino-5-(3'-indolomethylene)-1,3,4-thiadiazole(3) with various aromatic alde-hydes. Cycloaddition of thioglycolic acid to 4-8 yielded 3-[5-(3"indolo-methylene)-1',3',4'-thiadiazol-2'-yl]-2-substitdaryl-4-thiazolidinones and with diazonium salt solution of 4-8 gave I-[5'-(3"-indolomethylene]-2'-imino-l',3',4'-thiadiazol-2'-yl]-ll3-disubstitutedaryl)- formazans. These compounds were screened for anticonvulsant activity and acute toxicity. Compound 3-(3'-indolomethylene-I',3',4-thiadiazol-2'-yl)-2-(p-methoxy-phenyl)-4-thiazolidinones showed most potent anticonvulsant activity. The structure of all the synthesized compounds were delineated by element analysis, IR and proton magnetic resonance.


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