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Synthesis Of Nicorandil : An Antianginal Agent

Author(s): V. D Patil, C. L Viswanathan

Nicorandil, N-[2-nitroxyethyl]-pyridine-3-carboxamide was synthesized by condensing nicotinoyl chloride with 2-nitroxyethylamine in presence of pyridine. 2-Nitroxyethylamine was prepared from 2- aminoethanol by a three step process. This process was less hazardous and comparatively economical than the literature reported methods.


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