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Synthesis of some new heterocyclis compounds containing bridgehead nitrogen atom as antifungal drugs.

Author(s): H Singh, KN Shukla, R Dwivedi, L DS Yadav
Dept. of Chemistry, University of Gorakhpur, Gorakhpur 273 009,

Correspondence Address:
H Singh Dept. of Chemistry, University of Gorakhpur, Gorakhpur 273 009

Cyclocondensation of 3-aryl/5-methyl 1-2-hydrazinoimidazol-4-ones II (a-c) with 2,4-dichloro-phenoxy acetic acid, HCOOH, CICO2 ET and CS2 furnished a novel class of compound 7-aryl/5-methyl imidazo [2,1-c] -1,2,4-triazol-6-one and their analogues [III-VI (a-c)]. These have been compared with Diathane M-45, for their antifungal activity against A. niger and F. oxysporum.


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