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Abstract

Synthesis Of Sulphonamide Derivatives As Antimicrobial Agents

Author(s): S. D Trivedi, H. T Kubavat, H. H Parekh

Several 1-(N-arylsuphonylhydrazine carbonylmethyl)-2(1H)- quinoxalinones were prepared by condensing aryl sulphonylchloride with 2-(1H)-quinoxalinon-1'yl-acetyl hydrazine in presence of pyridine. The constitution of the products was supported by elemental analysis, IR, PMR and mass spectral study. The compounds synthesised were tested in vitro against Salmonella typhosa, Escherichia coli, Bacillus megaterium, and Stephylococcus citrus and a fungal strain, Aspergillus niger. Standard drugs were also tested under identical conditions for comparing the results.

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