All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Systemic Absorption Of Propranolol Hydrochloride From Buccoadhesive Films

Author(s): K Balamurugan, J. K Pandit, P. K Choudary, J Balasubramaniam

The systemic absorption of propranolol hydrochloride (PHL) delivered through rabbit oral mucosa was studied. Drug-loaded buccoadhesive films of varying compositions with unidirectional drug release were applied to rabbit oral mucosa and inhibition of isoprenaline-induced tachycardia was achieved. In vitro drug release followed zero-order kinetics. The ex vivo mucoadhesivity tests using rabbit small intestinal mucosa on an in-house fabricated apparatus yielded correlation between film composition and rnucoadhesivity. Selected batches of placebo films showing good bioadhesion and oral mucosal compatibility in human volunteers could form a basis of propronalol delivery through this route to avoid first pass metabolism.

PDF

 
 
List of Supporting Conferences