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Abstract

The Effect Of Aglaia Roxburghiana (W. & A.) Miq. Var. Beddomei On Experimentally - Induced Ulcers

Author(s): S Janaki, S Vishwanathan, V Vijayasekaran, S. S Parvathy, T. R Ramanujam, D Prathiba, K. R Rao

The ethanolic extracts of aerial parts and fruits of Aglaia roxburghiana were tested in rats for their effect on gastric secretion and ulcer formation in Shay rats and aspirin-induced ulcer model. Doses ranging from 100 to 400 mg/kg of the extracts were used in the experiment. The fruit extract produced a dose-dependent reduction of the free acidity whereas, a significant reduction in ulcer score was observed for both aerial part and fruit extracts. Both the extracts also offered significant protection against aspirin-induced ulcers. Histopathological observations support the ulcer protective effect of Aglaia roxburghiana. The present results agree with the use of Aglaia roxburghiana in traditional medicine against gastric ulceration.

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