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The Effect of Nursing Intervention on the Rehabilitation of Senile Dementia in Rapid Aging Rat Model

Author(s): H. Guo* and B. Bai1
College of Nursing, Shanxi Medical University, 1Departement of Neurology, Shanxi Medical University First Hospital, Taiyuan City 03001, China

Correspondence Address:
College of Nursing, Shanxi Medical University, Taiyuan City 03001, China, E-mail:

In order to study the effect and mechanism of nursing intervention based on music and exercise therapy on cognitive impairment in patients with senile dementia and to provide objective experimental basis for implementing clinical nursing measures, a rapid aging rat model was established. Rats were randomly divided into 5 groups, control group, homologous normal control group, music group, exercise group, music+exercise group to explore the mechanism of nursing intervention based on music and exercise therapy, and then 6 representative patients with mild to moderate senile dementia were selected as research subjects, divided into 3 groups with 2 patients in each group. Then, a nursing intervention based on music and exercise therapy was implemented. The results showed that there was no difference in the escape latent period between the experimental groups on the first day. On the second and third days, the control group had the longest escape latent period, but not significant compared to the other groups. There were no statistical differences between the remaining groups with different nursing interventions (p>0.05). Similarly, the escape latent period of the control group was the longest and significant on d 4 and 5 compared to the other groups. And the differences among the music group, the exercise group and the music+exercise group were not statistically significant. In addition, in the clinical evaluation of the rehabilitation effect of the nursing intervention in the senile dementia patients, the scores of the control group were lower than the scores of the experimental groups. Moreover, the experimental group had the largest change in scores before and after nursing intervention in neuropsychiatric symptoms. In the study of the mechanism of action of nursing intervention on senile dementia, it was found that nursing intervention can effectively improve the learning, memory and mimicry ability of rats, and also increased the content of choline acetyltransferase in hippocampus. In other words, the memory level of rats is related to the amount of choline acetyltransferase in the hippocampus. This also showed that nursing intervention had a great effect on the rehabilitation of patients with senile dementia.

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