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Abstract

The Effects of Propofol and Sevoflurane on Postoperative Delirium in Patients with Malignant Tumors

Author(s): S. Zhao, Y. Lu*, and X. Zhuang
Anesthesiology Department, Second Hospital, Tianjin Medical University, Tianjin 300211, China

Correspondence Address:
Anesthesiology Department, Second Hospital, Tianjin Medical University, Tianjin 300211, China, E-mail: [email protected]

In order to study the effects of propofol and sevoflurane on postoperative delirium in patients with malignant tumors, elderly patients who suffered from malignant tumors were selected as the research subjects and were divided into the propofol group and the sevoflurane group, who were induced anesthesia with Propofol and sevoflurane, respectively before surgery to observe the bispectral index, mean arterial pressure and heart rate of each patient before anesthesia, during the surgery, and in the recovery period. In addition, the mini-mental state examination was utilized to evaluate the mental status of patients, the confusion assessment model for intensive care unit was utilized to evaluate the conditions of postoperative delirium of patients, the Prince-Henry pain scale was utilized to evaluate the degree of postoperative pain of patients, and the enzyme-linked immunosorbent assay was utilized to detect the protein concentrations of NSE, S100β, and IL-2 of patients. The results showed that the bispectral index, mean arterial pressure and heart rate of patients decreased significantly during the surgery compared to those values before anesthesia, in both groups of patients(p<0.05); however, the inter-group differences in the bispectral index, mean arterial pressure and heart rate between the propofol group and the sevoflurane group were not statistically significant. In terms of the mini-mental state examination results of patients in the propofol group and the sevoflurane group, those obtained on the postoperative d 3 and postoperative d 5 were lower than those obtained on the preoperative 1d, and the differences were statistically significant (p<0.05); however, the inter-group differences of the mini-mental state examination results between the propofol group and the sevoflurane group were not statistically significant. In terms of the incidence rates of postoperative delirium in patients in the propofol group and the sevoflurane group, those on the postoperative d 3 were relatively higher, and the differences were statistically significant (p<0.05); however, the inter-group differences of the postoperative delirium incidence rates between the propofol group and the sevoflurane group were not statistically significant. In terms of the Prince-Henry pain scale results of patients in the propofol group and the sevoflurane group, respectively on postoperative d 1, 2, and 3, the intra-group differences were also not statistically significant, and the inter-group differences were not statistically significant. In terms of the ELISA results of the NSE, S100β, and IL-2 protein concentrations of patients in the propofol group and the sevoflurane group, the NSE and S100β protein concentrations were significantly increased on the postoperative d 1, 2 and 3 compared with those at preoperative 10 min (p<0.05); the IL-2 protein concentrations were not different between the preoperative 10 min and the postoperative d 1, 2 and 3 and the inter-group differences were also not significant. Anesthesia inductions with propofol or sevoflurane had influence on postoperative delirium of patients undergoing surgical treatment for malignant tumors.

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